Evidence based herbal drug standardization approach in coping with challenges of holistic management of diabetes: a dreadful lifestyle disorder of 21st century

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Arora, Rajesh 21-27 minutes

Journal of Diabetes & Metabolic Disorders volume 12, Article number: 35 (2013) Cite this article

Abstract

Plants by virtue of its composition of containing multiple constituents developed during its growth under various environmental stresses providing a plethora of chemical families with medicinal utility. Researchers are exploring this wealth and trying to decode its utility for enhancing health standards of human beings. Diabetes is dreadful lifestyle disorder of 21st century caused due to lack of insulin production or insulin physiological unresponsiveness. The chronic impact of untreated diabetes significantly affects vital organs. The allopathic medicines have five classes of drugs, or otherwise insulin in Type I diabetes, targeting insulin secretion, decreasing effect of glucagon, sensitization of receptors for enhanced glucose uptake etc. In addition, diet management, increased food fiber intake, Resistant Starch intake and routine exercise aid in managing such dangerous metabolic disorder. One of the key factors that limit commercial utility of herbal drugs is standardization. Standardization poses numerous challenges related to marker identification, active principle(s), lack of defined regulations, non-availability of universally acceptable technical standards for testing and implementation of quality control/safety standard (toxicological testing). The present study proposed an integrated herbal drug development & standardization model which is an amalgamation of Classical Approach of Ayurvedic Therapeutics, Reverse Pharmacological Approach based on Observational Therapeutics, Technical Standards for complete product cycle, Chemi-informatics, Herbal Qualitative Structure Activity Relationship and Pharmacophore modeling and, Post-Launch Market Analysis. Further studies are warranted to ensure that an effective herbal drug standardization methodology will be developed, backed by a regulatory standard guide the future research endeavors in more focused manner.

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Affiliations

  1. Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Marg, Delhi, IndiaRaman Chawla, Pallavi Thakur, Ayush Chowdhry, Anamika Sharma, Rajeev Goel, Jyoti Sharma, Smruti Sagar Priyadarshi, Vinod Kumar & Rakesh Kumar Sharma
  2. Department of Plant Sciences Room 4D70 – 51, Campus Drive College of Agriculture and Bioresources University of Saskatchewan Saskatoon, Saskatchewan, CanadaSarita Jaiswal
  3. Office of CC R&D (LS & IC), Defence Research and Development Organisation, DRDO Bhawan, New Delhi, IndiaRajesh Arora

Authors

  1. Raman ChawlaYou can also search for this author in PubMed Google Scholar
  2. Pallavi ThakurYou can also search for this author in PubMed Google Scholar
  3. Ayush ChowdhryYou can also search for this author in PubMed Google Scholar
  4. Sarita JaiswalYou can also search for this author in PubMed Google Scholar
  5. Anamika SharmaYou can also search for this author in PubMed Google Scholar
  6. Rajeev GoelYou can also search for this author in PubMed Google Scholar
  7. Jyoti SharmaYou can also search for this author in PubMed Google Scholar
  8. Smruti Sagar PriyadarshiYou can also search for this author in PubMed Google Scholar
  9. Vinod KumarYou can also search for this author in PubMed Google Scholar
  10. Rakesh Kumar SharmaYou can also search for this author in PubMed Google Scholar
  11. Rajesh AroraYou can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rajesh Arora.

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The authors declare that they have no competing interests.

Authors’ contributions

All authors contributed equally to this work. RC and PT wrote the main paper. RKS, RA, VC and AC reduced the data. SJ, AS, RG, JS and SSP wrote the Supplementary Information. All authors discussed the content and implications and commented on the manuscript at all stages. All authors contributed extensively to the work presented in this paper. All authors read and approved the final manuscript.

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Chawla, R., Thakur, P., Chowdhry, A. et al. Evidence based herbal drug standardization approach in coping with challenges of holistic management of diabetes: a dreadful lifestyle disorder of 21st century. J Diabetes Metab Disord 12, 35 (2013). https://doi.org/10.1186/2251-6581-12-35

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Keywords

  • Diabetes
  • Standardisation
  • Herbal drugs
  • Drug development